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MAEL Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q96JY0
Clone Names 90723217
Peptide ID 90723217
Additional Information
Gene ID 84944
Other Names Protein maelstrom homolog, MAEL
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8889b was selected from the C-term region of human MAEL. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAEL
Function Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP- bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage (By similarity).
Cellular Location Cytoplasm. Nucleus. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis Specifically localizes to piP-bodies, a subset of the nuage which contains secondary piRNAs (By similarity).
Tissue Location Testis-specific. Expressed in various cancer cell lines, probably due to demethylation of its promoter {ECO:0000269|PubMed:19693694, ECO:0000269|Ref.1}
Research Areas
Citations (0)

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Background

MAEL plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for localization of germ-cell factors to the meiotic nuage (By similarity).

References

Ehret,G.B., et.al., Eur. J. Hum. Genet. 17 (12), 1650-1657 (2009)Xiao,L., et.al., Mol. Biol. Rep. (2009)

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$ 80.00
Cat# BP8889b
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