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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   H3-S10 Antibody Blocking Peptide   

H3-S10 Antibody Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P84243
Clone Names 90625286
Peptide ID 90625286
Additional Information
Gene ID 3020;3021
Other Names Histone H33, H3F3A, H33A, H3F3
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8890a was selected from the region of human H3-S10. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name H3F3A
Synonyms H3.3A, H3F3
Function Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Cellular Location Nucleus. Chromosome.
Research Areas
Citations (0)

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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures.


Wells,D., Proc. Natl. Acad. Sci. U.S.A. 82 (9), 2834-2838 (1985)

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$ 80.00
Cat# BP8890a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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