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DNASE2 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O00115
Clone Names 90713056
Additional Information
Gene ID 1777
Other Names Deoxyribonuclease-2-alpha, Acid DNase, Deoxyribonuclease II alpha, DNase II alpha, Lysosomal DNase II, R31240_2, DNASE2, DNASE2A, DNL2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8894c was selected from the Center region of human DNASE2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DNASE2
Synonyms DNASE2A, DNL2
Function Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the clearance of nucleic acids generated through apoptosis, hence preventing autoinflammation (PubMed:29259162, PubMed:31775019). Necessary for proper fetal development and for definitive erythropoiesis in fetal liver and bone marrow, where it degrades nuclear DNA expelled from erythroid precursor cells (PubMed:29259162).
Cellular Location Lysosome.
Tissue Location Expressed in monocytes/macrophages (at protein level).
Research Areas
Citations (0)
citation

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Background

DNASE2 is a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis.

References

Yasuda,T., et.al., J. Biol. Chem. 273 (5), 2610-2616 (1998)

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$ 277.78
Cat# BP8894c
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Availability: 2 weeks
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