UNC13B Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O14795 |
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Clone Names | 90723131 |
Gene ID | 10497 |
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Other Names | Protein unc-13 homolog B, Munc13-2, munc13, UNC13B, UNC13 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8905c was selected from the Center region of human UNC13B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | UNC13B (HGNC:12566) |
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Synonyms | UNC13 |
Function | Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP) (By similarity). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release (By similarity). |
Cellular Location | Cytoplasm. Membrane; Peripheral membrane protein. Cell membrane Synapse. Note=Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding (By similarity) |
Tissue Location | Expressed in kidney cortical epithelial cells and brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
UNC13B plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. It is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). It is essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity).
References
Sjoeblom T., et.al., Science 314:268-274(2006).Yu L.-R., Zhu Z., et.al., J. Proteome Res. 6:4150-4162(2007).
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