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UNC13B Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession O14795
Clone Names 90723131
Peptide ID 90723131
Additional Information
Gene ID 10497
Other Names Protein unc-13 homolog B, Munc13-2, munc13, UNC13B, UNC13
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8905c was selected from the Center region of human UNC13B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name UNC13B
Synonyms UNC13
Function Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity- depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity).
Cellular Location Cytoplasm. Membrane; Peripheral membrane protein. Cell membrane. Cell junction, synapse Note=Localized to synapses. Translocated to the plasma membrane in response to phorbol ester binding (By similarity).
Tissue Location Expressed in kidney cortical epithelial cells and brain.
Research Areas
Citations (0)

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Background

UNC13B plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. It is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). It is essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity).

References

Sjoeblom T., et.al., Science 314:268-274(2006).Yu L.-R., Zhu Z., et.al., J. Proteome Res. 6:4150-4162(2007).

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$ 80.00
Cat# BP8905c
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