|Other Names||D-tyrosyl-tRNA(Tyr) deacylase 1, 31--, DNA-unwinding element-binding protein B, DUE-B, Histidyl-tRNA synthase-related, DTD1, C20orf88, DUEB, HARS2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8922b was selected from the C-term region of human DTD1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||C20orf88, DUEB, HARS2|
|Function||ATPase involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes. May hydrolyze D- tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr), a possible defense mechanism against a harmful effect of D-tyrosine.|
|Cellular Location||Nucleus. Cytoplasm Note=Associated with chromatin at some replication origins containing functional DNA-unwinding elements|
|Tissue Location||Expressed in many adult and fetal tissues. Highest levels in testis, ovary, spleen and in adult and fetal brain.|
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Provided below are standard protocols that you may find useful for product applications.
The protein is similar in sequence to histidyl-tRNA synthetase, which hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). The encoded protein is found in the cytoplasm.
Casper,J.M.,et.al., J. Biol. Chem. 280 (13), 13071-13083 (2005)
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