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DTX1 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q86Y01
Clone Names 90921143
Peptide ID 90921143
Additional Information
Gene ID 1840
Other Names E3 ubiquitin-protein ligase DTX1, 632-, Protein deltex-1, Deltex1, hDTX1, DTX1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8923c was selected from the Center region of human DTX1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DTX1
Function Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T- cell development, suggesting that it can antagonize NOTCH1.
Cellular Location Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Associates with endocytic vesicles. Partially nuclear
Tissue Location Widely expressed. Strongly expressed in blood vessel. Also expressed in embryonic nervous system, pancreas, lung, adrenal gland, digestive tube and muscles. Expressed in MZB cells and developing B- and T-cells.
Research Areas
Citations (0)

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DTX1 was identified as encoding a positive regulator of the Notch-signaling pathway in Drosophila. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity.


Wu,C.,, Proteomics 7 (11), 1775-1785 (2007)

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$ 80.00
Cat# BP8923c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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