|Other Names||Zinc finger protein DZIP1, DAZ-interacting protein 1/2, DZIP1, DZIP, DZIP2, KIAA0996|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8926c was selected from the Center region of human DZIP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||DZIP, DZIP2, KIAA0996|
|Function||May participate in spermatogenesis via its interaction with DAZ (PubMed:15081113). Has a role in primary cilium formation (PubMed:19852954).|
|Cellular Location||Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=In testis, it is predominantly nuclear, with some cytoplasmic localization in spermatogonia Colocalizes with DAZ and DAZL in primordial germ cells|
|Tissue Location||Predominantly expressed in testis. Also expressed in fetal brain, adult oocytes and ovary. Expressed in undifferentiated ES cells. In testis, it is probably specifically expressed in germ cells. Expressed in mature germ cells and secondary spermatocytes, while it is weakly or not expressed in primary spermatocytes.|
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Provided below are standard protocols that you may find useful for product applications.
DZIP1 may participate in spermatogenesis via its interaction with DAZ. Isoform 1 and isoform 2 interact with DAZ proteins. DZIP1 may also participate in a RNA-binding complex that functions in both ES cells and germ cells. There are three named isoforms.
Moore,F.L.,et.al., Genomics 83 (5), 834-843 (2004)
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