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HP Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P00738
Clone Names 90625093
Peptide ID 90625093
Additional Information
Gene ID 3240
Other Names Haptoglobin, Zonulin, Haptoglobin alpha chain, Haptoglobin beta chain, HP
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8929c was selected from the Center region of human HP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name HP
Function As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway.
Cellular Location Secreted.
Tissue Location Expressed by the liver and secreted in plasma.
Research Areas
Citations (0)

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HP is a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia.


Ryndel,M.,, Clin. Chim. Acta 411 (7-8), 500-504 (2010)Igl,W., PLoS Genet. 6 (1), E1000798 (2010)

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$ 80.00
Cat# BP8929c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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