|Other Names||Tribbles homolog 2, TRB-2, TRIB2 (HGNC:30809)|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8930a was selected from the N-term region of human TRIB2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity).|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton. Note=May associate with the cytoskeleton.|
|Tissue Location||Highly expressed in peripheral blood leukocytes.|
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TRIB2 is one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia.
Hegele,R.A., et.al., Hum. Mol. Genet. 18 (21), 4189-4194 (2009)Eder,K., et.al., Int. Immunol. 20 (12), 1543-1550 (2008)
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