TRIB2 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q92519 |
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Other Accession | NP_067675 |
Clone Names | 50908261 |
Gene ID | 28951 |
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Other Names | Tribbles homolog 2, TRB-2, TRIB2 (HGNC:30809) |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8930a was selected from the N-term region of human TRIB2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TRIB2 (HGNC:30809) |
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Function | Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity). |
Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton. Note=May associate with the cytoskeleton. |
Tissue Location | Highly expressed in peripheral blood leukocytes. |
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Provided below are standard protocols that you may find useful for product applications.
Background
TRIB2 is one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia.
References
Hegele,R.A., et.al., Hum. Mol. Genet. 18 (21), 4189-4194 (2009)Eder,K., et.al., Int. Immunol. 20 (12), 1543-1550 (2008)
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