|Other Names||Tribbles homolog 2, TRB-2, TRIB2 (HGNC:30809)|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8930a was selected from the N-term region of human TRIB2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity).|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton. Note=May associate with the cytoskeleton.|
|Tissue Location||Highly expressed in peripheral blood leukocytes.|
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
TRIB2 is one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia.
Hegele,R.A., et.al., Hum. Mol. Genet. 18 (21), 4189-4194 (2009)Eder,K., et.al., Int. Immunol. 20 (12), 1543-1550 (2008)
If you have any additional inquiries please email technical services at email@example.com.