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ALDH18A1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P54886 |
|---|---|
| Clone Names | 90429017 |
| Gene ID | 5832 |
|---|---|
| Other Names | Delta-1-pyrroline-5-carboxylate synthase, P5CS, Aldehyde dehydrogenase family 18 member A1, Glutamate 5-kinase, GK, Gamma-glutamyl kinase, Gamma-glutamyl phosphate reductase, GPR, Glutamate-5-semialdehyde dehydrogenase, Glutamyl-gamma-semialdehyde dehydrogenase, ALDH18A1, GSAS, P5CS, PYCS |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP8938c was selected from the Center region of human ALDH18A1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ALDH18A1 |
|---|---|
| Synonyms | GSAS, P5CS, PYCS |
| Function | Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine. |
| Cellular Location | Mitochondrion inner membrane |
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Provided below are standard protocols that you may find useful for product applications.
Background
ALDH18A1 is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine and arginine.
References
Hu,C.A., et.al., Amino Acids 35 (4), 665-672 (2008)Bicknell,L.S., et.al., Eur. J. Hum. Genet. 16 (10), 1176-1186 (2008)
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