|Other Names||Ras association domain-containing protein 4, RASSF4|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8942c was selected from the Center region of human RASSF4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Potential tumor suppressor. May act as a KRAS effector protein. May promote apoptosis and cell cycle arrest.|
|Tissue Location||Widely expressed. Frequently down-regulated in tumor cell lines.|
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The function of RASSF4 has not yet been determined but it may involve a role in tumor suppression. RASSF4 may act as a KRAS effector protein and may promote apoptosis and cell cycle arrest. Alternative splicing of this gene results in several transcript variants; however, most of the variants have not been fully described.
French,D., et.al., Blood 113 (19), 4512-4520 (2009)Grupe,A., et.al., Am. J. Hum. Genet. 78 (1), 78-88 (2006)
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