|Other Names||Alkaline ceramidase 3, AlkCDase 3, Alkaline CDase 3, 351-, Alkaline dihydroceramidase SB89, Alkaline phytoceramidase, aPHC, ACER3, APHC, PHCA|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8953b was selected from the C-term region of human ACER3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. Does not have reverse activity.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein|
|Tissue Location||Ubiquitously expressed. Highest expression in placenta|
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Provided below are standard protocols that you may find useful for product applications.
ACER3 hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. Does not have reverse activity.
Wheeler,H.E., et.al., PLoS Genet. 5 (10), E1000685 (2009)Mao,C. et.al., Biochim. Biophys. Acta 1781 (9), 424-434 (2008)
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