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ACMSD Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q8TDX5
Clone Names 90819032
Peptide ID 90819032
Additional Information
Gene ID 130013
Other Names 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase, Picolinate carboxylase, ACMSD
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8954a was selected from the N-term region of human ACMSD. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.
Research Areas
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ACMSD is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS).ACMSD (ACMS decarboxylase; EC can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.


Garavaglia,S.,, FEBS J. 276 (22), 6615-6623 (2009)Fukuoka,S.,, J. Biol. Chem. 277 (38), 35162-35167 (2002)

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$ 80.00
Cat# BP8954a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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