|Other Names||TATA-binding protein-associated factor 172, 364-, ATP-dependent helicase BTAF1, B-TFIID transcription factor-associated 170 kDa subunit, TAF(II)170, TBP-associated factor 172, TAF-172, BTAF1, TAF172|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulates transcription in association with TATA binding protein (TBP). Removes TBP from the TATA box in an ATP-dependent manner.|
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Provided below are standard protocols that you may find useful for product applications.
Initiation of transcription by RNA polymerase II requiresthe assistance of TATA box-binding protein (TBP; MIM 600075) andTBP-associated factors, or TAFs (e.g., TAF2B; MIM 604912), in 2distinct complexes, TFIID and B-TFIID. The TFIID complex iscomposed of TBP and more than 8 TAFs. However, the majority of TBPis present in the B-TFIID complex, which is composed of TBP andTAFII170, also called TAF172, and has DNA-dependent ATPaseactivity.
Koutroubas, G., et al. Mol. Cell. Biol. 28(3):926-938(2008)Grob, P., et al. Structure 14(3):511-520(2006)Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
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