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GRB14 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q14449
Clone Names 90415091
Peptide ID 90415091
Additional Information
Gene ID 2888
Other Names Growth factor receptor-bound protein 14, GRB14 adapter protein, GRB14
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8969a was selected from the N-term region of human GRB14. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GRB14
Function Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.
Cellular Location Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Note=Upon insulin stimulation, translocates to the plasma membrane
Tissue Location Expressed at high levels in the liver, kidney, pancreas, testis, ovary, heart and skeletal muscle
Research Areas
Citations (0)

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GRB14 is a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling.


Jones,N.,, J. Biol. Chem. 274 (43), 30896-30905 (1999)Reilly,J.F.,, J. Biol. Chem. 275 (11), 7771-7778 (2000)

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$ 80.00
Cat# BP8969a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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