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ALO17 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q63HN8
Other Accession Q9HCF4
Clone Names 91019004
Peptide ID 91019004
Additional Information
Gene ID 57674
Other Names E3 ubiquitin-protein ligase RNF213, 632-, ALK lymphoma oligomerization partner on chromosome 17, Mysterin, RING finger protein 213, RNF213, ALO17, C17orf27, KIAA1554, KIAA1618, MYSTR
Target/Specificity The synthetic peptide sequence used to generate the antibody AP8991b was selected from the C-term region of human ALO17. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RNF213 (HGNC:14539)
Function E3 ubiquitin-protein ligase involved in angiogenesis (PubMed:21799892, PubMed:26278786, PubMed:26766444, PubMed:26126547). Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression (PubMed:26766444). Also has ATPase activity (PubMed:24658080, PubMed:26126547).
Cellular Location Cytoplasm, cytosol
Tissue Location Widely expressed (at protein level).
Research Areas
Citations (0)

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Background

There are three isoforms. A chromosomal aberration involving KIAA1618 is associated with anaplastic large-cell lymphoma (ALCL).

References

Choudhary C., et.al., Science 325:834-840(2009).Mayya V., et.al., Sci. Signal. 2:RA46-RA46(2009).

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$ 80.00
Cat# BP8991b
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