|Other Names||Low affinity immunoglobulin gamma Fc region receptor II-c, IgG Fc receptor II-c, CDw32, Fc-gamma RII-c, Fc-gamma-RIIc, FcRII-c, CD32, FCGR2C, CD32, FCG2, IGFR2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP8992b was selected from the C-term region of human FCGR2C. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CD32, FCG2, IGFR2|
|Function||Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells.|
|Cellular Location||Isoform IIC4: Cytoplasm. Isoform IIC2: Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Isoform IIC1 is detected in monocytes, macrophages, polymorphonuclear cells and natural killer cells|
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Provided below are standard protocols that you may find useful for product applications.
FCGR2C is the receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. It is involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells.
Metes D., et.al., Blood 91:2369-2380(1998).Stuart S.G.,et.al., EMBO J. 8:3657-3666(1989).
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