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CLTA Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P09496
Clone Names 90904104
Peptide ID 90904104
Additional Information
Gene ID 1211
Other Names Clathrin light chain A, Lca, CLTA
Target/Specificity The synthetic peptide sequence used to generate the antibody AP9008c was selected from the Center region of human CLTA. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CLTA
Function Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as component of the TACC3/ch- TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter- microtubule bridge (PubMed:15858577, PubMed:21297582).
Cellular Location Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, spindle. Note=Cytoplasmic face of coated pits and vesicles. In complex with TACC3 and CKAP5 (forming the TACC3/ch-TOG/clathrin complex) localized to inter-microtubule bridges in mitotic spindles.
Research Areas
Citations (0)

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Background

Clathrin is a large, soluble protein composed of heavy and light chains. It functions as the main structural component of the lattice-type cytoplasmic face of coated pits and vesicles which entrap specific macromolecules during receptor-mediated endocytosis. CLTA is one of two clathrin light chain proteins which are believed to function as regulatory elements.

References

Wong,D.H., et.al., J. Neurosci. 10 (9), 3025-3031 (1990)Nathke,I., et.al., J. Biol. Chem. 265 (30), 18621-18627 (1990)

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$ 80.00
Cat# BP9008c
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