|Other Names||Calmegin, CLGN|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9022c was selected from the Center region of human CLGN. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions (By similarity).|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type I membrane protein|
|Tissue Location||Detected in testis (at protein level). Detected in testis.|
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Provided below are standard protocols that you may find useful for product applications.
CLGN probably plays an important role in spermatogenesis. Binds calcium ions.
van Lith M., et.al., Mol. Biol. Cell 18:2795-2804(2007).
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