|Other Names||Caspase recruitment domain-containing protein 6, CARD6|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9043c was selected from the Center region of human CARD6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in apoptosis.|
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Provided below are standard protocols that you may find useful for product applications.
CARD6 is a protein that contains a caspase recruitment domain (CARD), an antiparallel six-helical bundle that mediates homotypic protein-protein interactions. The encoded protein is a microtubule-associated protein that has been shown to interact with receptor-interacting protein kinases and positively modulate signal transduction pathways converging on activation of the inducible transcription factor NF-kB.
Kim,S.S., et.al., Pathology 42 (1), 50-53 (2010)Olsen,J.V., et.al., Cell 127 (3), 635-648 (2006)
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