|Other Names||Prenylated Rab acceptor protein 1, PRA1 family protein 1, RABAC1, PRA1, PRAF1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9049a was selected from the N-term region of human RABAC1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||General Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI (By similarity).|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cytoplasm. Golgi apparatus. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Note=According to some authors, it is an integral membrane protein, while others showed that it is cytoplasmic and membrane-associated to Golgi and synaptic vesicles.|
|Tissue Location||Ubiquitous. Strongest expression found in placenta, pituitary gland, kidney, lung and stomach|
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RABAC1 is general Rab protein regulator required for vesicle formation from the Golgi complex. May control vesicle docking and fusion by mediating the action of Rab GTPases to the SNARE complexes. In addition it inhibits the removal of Rab GTPases from the membrane by GDI.
Venkatesan,K., et.al., Nat. Methods 6 (1), 83-90 (2009)Kim,J.T., et.al., Biochem. Biophys. Res. Commun. 349 (1), 200-208 (2006)
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