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ORC6L Antibody (C-term E213) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9Y5N6
Clone Names 80522080
Peptide ID 80522080
Additional Information
Gene ID 23594
Other Names Origin recognition complex subunit 6, ORC6, ORC6L
Target/Specificity The synthetic peptide sequence used to generate the antibody AP9057b was selected from the C-term region of human ORC6L. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ORC6
Synonyms ORC6L
Function Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre- replication complex necessary to initiate DNA replication. Does not bind histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.
Cellular Location Nucleus.
Research Areas
Citations (0)

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ORC6L is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. It has been shown that this protein and ORC1L are loosely associated with the core complex consisting of ORC2L, -3L, -4L and -5L. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis.


Balasov,M.,, Proc. Natl. Acad. Sci. U.S.A. 106 (26), 10672-10677 (2009)Gavin,E.J.,, PLoS ONE 3 (12), E4054 (2008)

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$ 80.00
Cat# BP9057b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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