|Other Names||Phylloquinone omega-hydroxylase CYP4F11, 3-hydroxy fatty acids omega-hydroxylase CYP4F11, 11413-, Cytochrome P450 4F11, CYPIVF11, CYP4F11 (HGNC:13265)|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9058a was selected from the N-term region of human CYP4F11. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Omega-hydroxylase that oxidizes a variety of structurally unrelated compounds, including fatty acids and xenobiotics. Plays a key role in vitamin K catabolism by mediating omega-hydroxylation of vitamin K1 (phylloquinone), and menaquinone-4 (MK-4), a form of vitamin K2. Hydroxylation of phylloquinone and MK-4 probably regulates blood coagulation (PubMed:24138531). Catalyzes omega-hydroxylation of 3-hydroxy fatty acids, such as 3-hydroxypalmitate, 3-hydroxyoleate, 3- hydroxyarachidonate, and 3-hydroxystearate (PubMed:18065749, PubMed:19932081). Oxidizes drugs such as erythromycin, benzphetamine, ethylmorphine, chlorpromazine and imipramine (PubMed:15364545).|
|Cellular Location||Microsome membrane; Single-pass membrane protein|
|Tissue Location||Expressed mainly in human liver, followed by kidney, heart, and skeletal muscle.|
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Provided below are standard protocols that you may find useful for product applications.
CYP4F11 encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F2, is approximately 16 kb away.
Wang,Y., et.al., Drug Metab. Dispos. 38 (1), 100-107 (2010)Dhar,M., et.al., J. Lipid Res. 49 (3), 612-624 (2008)
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