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CYP4F2 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P78329
Clone Names 80317117
Peptide ID 80317117
Additional Information
Gene ID 8529
Other Names Phylloquinone omega-hydroxylase CYP4F2, 20-hydroxyeicosatetraenoic acid synthase, 20-HETE synthase, 11413-, Arachidonic acid omega-hydroxylase, CYPIVF2, Cytochrome P450 4F2, Cytochrome P450-LTB-omega, Leukotriene-B(4) 20-monooxygenase 1, Leukotriene-B(4) omega-hydroxylase 1, CYP4F2 (HGNC:2645)
Target/Specificity The synthetic peptide sequence used to generate the antibody AP9059a was selected from the N-term region of human CYP4F2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CYP4F2 (HGNC:2645)
Function Omega-hydroxylase that oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids and xenobiotics. Plays a key role in vitamin K catabolism by mediating omega-hydroxylation of vitamin K1 (phylloquinone), and menaquinone-4 (MK-4), a form of vitamin K2. Hydroxylation of phylloquinone and MK-4 probably regulates blood coagulation (PubMed:19297519, PubMed:24138531). Also shows arachidonic acid omega-hydroxylase activity in kidney, by mediating conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), possibly influencing blood pressure control (PubMed:10660572, PubMed:17341693, PubMed:18574070). Also acts as a leukotriene-B(4) omega-hydroxylase by mediating conversion of leukotriene-B(4) (LTB4) to its omega-hydroxylated metabolite 20-hydroxyleukotriene- B(4) (20-OH LTB4) (PubMed:8026587, PubMed:9799565).
Cellular Location Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein
Tissue Location Liver. Also present in kidney: specifically expressed in the S2 and S3 segments of proximal tubules in cortex and outer medulla (PubMed:10660572).
Research Areas
Citations (0)

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CYP4F2 encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This protein is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away.


Perini,J.A.,, Clin. Pharmacol. Ther. 87 (4), 417-420 (2010)Cavallari,L.H.,, Clin. Pharmacol. Ther. 87 (4), 459-464 (2010)

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$ 80.00
Cat# BP9059a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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