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BPI Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P17213 |
|---|---|
| Clone Names | 80311208 |
| Gene ID | 671 |
|---|---|
| Other Names | Bactericidal permeability-increasing protein, BPI, CAP 57, BPI |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP9060c was selected from the Center region of human BPI. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | BPI |
|---|---|
| Function | The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. |
| Cellular Location | Secreted. Cytoplasmic granule membrane Note=Membrane-associated in polymorphonuclear Leukocytes (PMN) granules. |
| Tissue Location | Restricted to cells of the myeloid series. |
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Provided below are standard protocols that you may find useful for product applications.
Background
BPI encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has bactericidal activity on gram-negative organisms.
References
Davila,S., et.al., Genes Immun. (2010) In pressGuey,L.T., et.al., Eur. Urol. 57 (2), 283-292 (2010)
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