|Other Names||Bactericidal permeability-increasing protein, BPI, CAP 57, BPI|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9060c was selected from the Center region of human BPI. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.|
|Cellular Location||Secreted. Cytoplasmic granule membrane Note=Membrane-associated in polymorphonuclear Leukocytes (PMN) granules.|
|Tissue Location||Restricted to cells of the myeloid series.|
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Provided below are standard protocols that you may find useful for product applications.
BPI encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has bactericidal activity on gram-negative organisms.
Davila,S., et.al., Genes Immun. (2010) In pressGuey,L.T., et.al., Eur. Urol. 57 (2), 283-292 (2010)
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