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ADHFE1 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8IWW8 |
|---|---|
| Clone Names | 90819065 |
| Gene ID | 137872 |
|---|---|
| Other Names | Hydroxyacid-oxoacid transhydrogenase, mitochondrial, HOT, Alcohol dehydrogenase iron-containing protein 1, ADHFe1, Fe-containing alcohol dehydrogenase, ADHFE1 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP9062c was selected from the Center region of human ADHFE1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ADHFE1 |
|---|---|
| Function | Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). D,L-3-hydroxyisobutyrate and L-3-hydroxybutyrate (L-3-OHB) are also substrates for HOT with 10-fold lower activities. |
| Cellular Location | Mitochondrion. |
| Tissue Location | Only expressed in adult liver. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The ADHFE1 protein encodes hydroxyacid-oxoacid transhydrogenase (EC 1.1.99.24), which is responsible for the oxidation of 4-hydroxybutyrate in mammalian tissues.
References
Lyon,R.C., et.al., Chem. Biol. Interact. 178 (1-3), 283-287 (2009)Kardon,T., et.al., FEBS Lett. 580 (9), 2347-2350 (2006)
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