|Other Names||Microsomal triglyceride transfer protein large subunit, MTTP, MTP|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9069b was selected from the C-term region of human MTTP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (PubMed:23475612, PubMed:8939939, PubMed:26224785, PubMed:25108285, PubMed:22236406). Required for the secretion of plasma lipoproteins that contain apolipoprotein B (PubMed:23475612, PubMed:8939939, PubMed:26224785).|
|Cellular Location||Endoplasmic reticulum. Note=Colocalizes with P4HB/PDI in the endoplasmic reticulum (PubMed:23475612, PubMed:26224785)|
|Tissue Location||Liver and small intestine. Also found in ovary, testis and kidney.|
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Provided below are standard protocols that you may find useful for product applications.
MTTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a entral role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia.
Dai,K., et.al., Arterioscler. Thromb. Vasc. Biol. 30 (3), 568-574 (2010)Oliveira,C.P., et.al., J. Gastroenterol. Hepatol. 25 (2), 357-361 (2010)
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