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MCM5 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P33992
Other Accession NP_006730
Clone Names 80109142
Peptide ID 80109142
Additional Information
Gene ID 4174
Other Names DNA replication licensing factor MCM5, CDC46 homolog, P1-CDC46, MCM5, CDC46
Target/Specificity The synthetic peptide sequence used to generate the antibody AP9078b was selected from the C-term region of human MCM5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MCM5
Synonyms CDC46
Function Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity). Interacts with MCMBP.
Cellular Location Nucleus.
Research Areas
Citations (0)

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MCM5 is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation.


Saade,E.,, Proteomics 9 (21), 4934-4943 (2009)Snyder,M.,, J. Biol. Chem. 284 (20), 13466-13472 (2009)

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$ 80.00
Cat# BP9078b
(40 western blots)
Availability: In Stock
Bulk Size
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