|Other Names||60S acidic ribosomal protein P0, 60S ribosomal protein L10E, RPLP0|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9086b was selected from the Center region of human RPLP0. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Ribosomal protein P0 is the functional equivalent of E.coli protein L10.|
|Cellular Location||Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:19188445, PubMed:17289661).|
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Provided below are standard protocols that you may find useful for product applications.
RPLP0 was catalyze systhesis by ribosomes, consisting of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This peotein encodes a ribosomal protein that is a component of the 60S subunit. The protein, which is the functional equivalent of the E. coli L10 ribosomal protein, belongs to the L10P family of ribosomal proteins. It is a neutral phosphoprotein with a C-terminal end that is nearly identical to the C-terminal ends of the acidic ribosomal phosphoproteins P1 and P2. This protein can interact with P1 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm.
Rinne,T., et.al., Hum. Mol. Genet. 17 (13), 1968-1977 (2008)Chang,T.W., et.al., Oncogene 27 (3), 332-338 (2008)
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