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UROS Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P10746
Clone Names 90415026
Peptide ID 90415026
Additional Information
Gene ID 7390
Other Names Uroporphyrinogen-III synthase, UROIIIS, UROS, Hydroxymethylbilane hydrolyase [cyclizing], Uroporphyrinogen-III cosynthase, UROS
Target/Specificity The synthetic peptide sequence used to generate the antibody AP9091a was selected from the N-term region of human UROS. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name UROS
Function Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme).
Tissue Location Ubiquitous..
Research Areas
Citations (0)

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Background

The protein encoded by this gene catalyzes the fourth step of porphyrin biosynthesis in the heme biosynthetic pathway. Defects in this gene cause congenital erythropoietic porphyria (Gunther's disease).

References

Bishop,D.F., et.al., Blood 115 (5), 1062-1069 (2010)Fortian,A., et.al., Biochemistry 48 (2), 454-461 (2009)

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$ 80.00
Cat# BP9091a
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