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ADRBK2 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P35626
Clone Names 90429010
Additional Information
Gene ID 157
Other Names Beta-adrenergic receptor kinase 2, Beta-ARK-2, G-protein-coupled receptor kinase 3, ADRBK2, BARK2, GRK3
Target/Specificity The synthetic peptide sequence used to generate the antibody AP9092a was selected from the N-term region of human ADRBK2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GRK3 (HGNC:290)
Function Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors.
Cellular Location Postsynapse {ECO:0000250|UniProtKB:P26819}. Presynapse {ECO:0000250|UniProtKB:P26819}
Research Areas
Citations (0)
citation

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Background

ADRBK2 is the beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function.

References

Gratacos,M., et.al., Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009)Rao,J.S., et.al., Int. J. Neuropsychopharmacol. 12 (6), 851-860 (2009)

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$ 277.78
Cat# BP9092a
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