|Other Names||EGF-containing fibulin-like extracellular matrix protein 1, Extracellular protein S1-5, Fibrillin-like protein, Fibulin-3, FIBL-3, EFEMP1, FBLN3, FBNL|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9095a was selected from the N-term region of human EFEMP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth.|
|Cellular Location||Secreted, extracellular space. Secreted, extracellular space, extracellular matrix Note=Localizes to the lamina propria underneath the olfactory epithelium.|
|Tissue Location||In the eye, associated with photoreceptor outer and inner segment regions, the nerve fiber layer, outer nuclear layer and inner and outer plexiform layers of the retina|
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Provided below are standard protocols that you may find useful for product applications.
EFEMP1 encodes a member of the fibulin family of extracellular matrix glycoproteins. Like all members of this family, the encoded protein contains tandemly repeated epidermal growth factor-like repeats followed by a C-terminus fibulin-type domain. This gene is upregulated in malignant gliomas and may play a role in the aggressive nature of these tumors.
Okada,Y., et.al., Hum. Mol. Genet. (2010) In pressWakabayashi,T., et.al., Biochem. Biophys. Res. Commun. 391 (1), 1116-1121 (2010)
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