|Other Names||Kinesin-like protein KIF11, Kinesin-like protein 1, Kinesin-like spindle protein HKSP, Kinesin-related motor protein Eg5, Thyroid receptor-interacting protein 5, TR-interacting protein 5, TRIP-5, KIF11, EG5, KNSL1, TRIP5|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9097a was selected from the N-term region of human KIF11. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||EG5, KNSL1, TRIP5|
|Function||Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton, spindle pole|
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Provided below are standard protocols that you may find useful for product applications.
KIF11 belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis.
Tcherniuk,S., et.al., Biochem. Pharmacol. 79 (6), 864-872 (2010)Parke,C.L., et.al., J. Biol. Chem. 285 (8), 5859-5867 (2010)
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