|Other Names||Spermatogenesis-defective protein 39 homolog, hSPE-39, VPS33B-interacting protein in apical-basolateral polarity regulator, VPS33B-interacting protein in polarity and apical restriction, VIPAS39, C14orf133, SPE39, VIPAR|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9104c was selected from the Center region of human C14orf133. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||C14orf133, SPE39, VIPAR|
|Function||Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A- dependent recycling pathway and in the maintenance of the apical- basolateral polarity (PubMed:20190753). May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be indepenedent of VPS33B (PubMed:19109425). May play a role in vesicular trafficking during spermatogenesis (By similarity). May be involved in direct or indirect transcriptional regulation of E- cadherin (By similarity).|
|Cellular Location||Cytoplasm. Cytoplasmic vesicle. Early endosome Recycling endosome. Late endosome. Note=Colocalizes in clusters with VPS33B at cytoplasmic organelles (PubMed:19109425)|
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Provided below are standard protocols that you may find useful for product applications.
Zhu,G.D., et.al., Mol. Biol. Cell 20 (4), 1223-1240 (2009)Rush,J., et.al., Nat. Biotechnol. 23 (1), 94-101 (2005)
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