|Other Names||Spermatogenesis-defective protein 39 homolog, hSPE-39, VPS33B-interacting protein in apical-basolateral polarity regulator, VPS33B-interacting protein in polarity and apical restriction, VIPAS39, C14orf133, SPE39, VIPAR|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9104c was selected from the Center region of human C14orf133. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||C14orf133, SPE39, VIPAR|
|Function||May play a role in vesicular trafficking during spermatogenesis (By similarity). Plays a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes. May play a role in epithelial polarization through stabilization of apical membrane protein content, possibly via the RAB11A-dependent apical recycling pathway. Also involved in direct or indirect transcriptional regulation of E-cadherin.|
|Cellular Location||Cytoplasm. Cytoplasmic vesicle. Early endosome. Recycling endosome. Late endosome Note=Colocalizes in clusters with VPS33B at cytoplasmic organelles.|
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Zhu,G.D., et.al., Mol. Biol. Cell 20 (4), 1223-1240 (2009)Rush,J., et.al., Nat. Biotechnol. 23 (1), 94-101 (2005)
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