|Other Names||Calcineurin subunit B type 1, Protein phosphatase 2B regulatory subunit 1, Protein phosphatase 3 regulatory subunit B alpha isoform 1, PPP3R1, CNA2, CNB|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9109a was selected from the N-term region of human PPP3R1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.|
|Cellular Location||Cytoplasm, cytosol. Cell membrane. Cell membrane, sarcolemma Note=Translocates from the cytosol to the sarcolemma in a CIB1- dependent manner during cardiomyocytes hypertrophy.|
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Provided below are standard protocols that you may find useful for product applications.
PPP3R1 is regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
Yerges,L.M., et.al., J. Bone Miner. Res. 24 (12), 2039-2049 (2009)Rodriguez,A., et.al., Mol. Cell 33 (5), 616-626 (2009)
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