|Other Names||Norrin, Norrie disease protein, X-linked exudative vitreoretinopathy 2 protein, NDP, EVR2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9110a was selected from the N-term region of human NDP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.|
|Tissue Location||Expressed in the outer nuclear, inner nuclear and ganglion cell layers of the retina, and in fetal and adult brain.|
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Provided below are standard protocols that you may find useful for product applications.
NDP encodes a secreted protein with a cystein-knot motif that activates the Wnt/beta-catenin pathway. The protein forms disulfide-linked oligomers in the extracellular matrix.
Ohlmann,A., et.al., J. Neurosci. 30 (1), 183-193 (2010)Aponte,E.P., et.al., Ophthalmic Genet. 30 (2), 99-102 (2009)
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