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NDP Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q00604
Clone Names 90504007
Additional Information
Gene ID 4693
Other Names Norrin, Norrie disease protein, X-linked exudative vitreoretinopathy 2 protein, NDP, EVR2
Target/Specificity The synthetic peptide sequence used to generate the antibody AP9110a was selected from the N-term region of human NDP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NDP
Synonyms EVR2
Function Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt- dependent activation of FZD4, suggesting the existence of a Wnt- independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction.
Cellular Location Secreted.
Tissue Location Expressed in the outer nuclear, inner nuclear and ganglion cell layers of the retina, and in fetal and adult brain
Research Areas
Citations (0)
citation

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Background

NDP encodes a secreted protein with a cystein-knot motif that activates the Wnt/beta-catenin pathway. The protein forms disulfide-linked oligomers in the extracellular matrix.

References

Ohlmann,A., et.al., J. Neurosci. 30 (1), 183-193 (2010)Aponte,E.P., et.al., Ophthalmic Genet. 30 (2), 99-102 (2009)

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$ 277.78
Cat# BP9110a
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