NDP Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q00604 |
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Clone Names | 90504007 |
Gene ID | 4693 |
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Other Names | Norrin, Norrie disease protein, X-linked exudative vitreoretinopathy 2 protein, NDP, EVR2 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP9110a was selected from the N-term region of human NDP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | NDP |
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Synonyms | EVR2 |
Function | Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt- dependent activation of FZD4, suggesting the existence of a Wnt- independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction. |
Cellular Location | Secreted. |
Tissue Location | Expressed in the outer nuclear, inner nuclear and ganglion cell layers of the retina, and in fetal and adult brain |
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Provided below are standard protocols that you may find useful for product applications.
Background
NDP encodes a secreted protein with a cystein-knot motif that activates the Wnt/beta-catenin pathway. The protein forms disulfide-linked oligomers in the extracellular matrix.
References
Ohlmann,A., et.al., J. Neurosci. 30 (1), 183-193 (2010)Aponte,E.P., et.al., Ophthalmic Genet. 30 (2), 99-102 (2009)
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