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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   IL10 Antibody (Center) Blocking Peptide   

IL10 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P22301
Clone Names 90504071
Peptide ID 90504071
Additional Information
Gene ID 3586
Other Names Interleukin-10, IL-10, Cytokine synthesis inhibitory factor, CSIF, IL10
Target/Specificity The synthetic peptide sequence used to generate the antibody AP9112c was selected from the Center region of human IL10. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL10
Function Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.
Cellular Location Secreted.
Tissue Location Produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types
Research Areas
Citations (0)

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The protein is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.


Trajkov,D.,, Indian J Tuberc 56 (3), 117-131 (2009)Kim,J.M.,, J. Immunol. 148 (11), 3618-3623 (1992)

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$ 80.00
Cat# BP9112c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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Ordering Information

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