|Other Names||cAMP-responsive element modulator, Inducible cAMP early repressor, ICER, CREM|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9122b was selected from the C-term region of human CREM. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550).|
|Tissue Location||Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes|
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Provided below are standard protocols that you may find useful for product applications.
CREM is a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes.
Fujimoto,T., et.al., J. Biochem. 115 (2), 298-303 (1994)
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