|Other Names||Podocin, NPHS2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9131a was selected from the N-term region of human NPHS2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton.|
|Cellular Location||Isoform 1: Cell membrane; Peripheral membrane protein|
|Tissue Location||Almost exclusively expressed in the podocytes of fetal and mature kidney glomeruli|
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Provided below are standard protocols that you may find useful for product applications.
NPHS2 is the glomerular protein podocin which plays a role in the regulation of glomerular permeability, and acts as a linker between the plasma membrane and the cytoskeleton. SRN is characterized by onset between three months and five years, resistance to steroid therapy and rapid progression to end-stage renal disease.
Boute,N., et.al., Nat. Genet. 24 (4), 349-354 (2000)
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