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NPHS2 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9NP85 |
|---|
| Gene ID | 7827 |
|---|---|
| Other Names | Podocin, NPHS2 |
| Target/Specificity | The synthetic peptide sequence used to generate the antibody AP9131a was selected from the N-term region of human NPHS2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NPHS2 |
|---|---|
| Function | Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton. |
| Cellular Location | [Isoform 1]: Cell membrane; Peripheral membrane protein |
| Tissue Location | Almost exclusively expressed in the podocytes of fetal and mature kidney glomeruli |
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Provided below are standard protocols that you may find useful for product applications.
Background
NPHS2 is the glomerular protein podocin which plays a role in the regulation of glomerular permeability, and acts as a linker between the plasma membrane and the cytoskeleton. SRN is characterized by onset between three months and five years, resistance to steroid therapy and rapid progression to end-stage renal disease.
References
Boute,N., et.al., Nat. Genet. 24 (4), 349-354 (2000)
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