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CDC20 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q12834
Clone Names 90904032
Peptide ID 90904032
Additional Information
Gene ID 991
Other Names Cell division cycle protein 20 homolog, p55CDC, CDC20
Target/Specificity The synthetic peptide sequence used to generate the antibody AP9138a was selected from the N-term region of human CDC20. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDC20
Function Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.
Cellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle pole
Research Areas
Citations (0)

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CDC20 is an activating regulatory factor for the APC/C (anaphase promoting complex/cyclosome). It activates the ubiquitination activity of the APC/C. CDC20 confers a strict destruction-box (D-box) dependence on APC. Levels of CDC20, as well as its binding to APC, peak in mitosis and decrease drastically at early G1.


Ge S.,, Cell Cycle 8:167-171(2009).Gauci S.,, Anal. Chem. 81:4493-4501(2009).

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$ 80.00
Cat# BP9138a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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