|Other Names||A/G-specific adenine DNA glycosylase, 322-, MutY homolog, hMYH, MUTYH, MYH|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9161c was selected from the Center region of human MUTYH. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2- OH-A DNA glycosylase activities.|
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Provided below are standard protocols that you may find useful for product applications.
MYH is the eukaryotic homolog to the E. coli protein MutY. It was first identified in HeLa cells and nicks DNA replication errors, specifically A/G mismatches. MYH is involved in oxidative DNA damage repair. It initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. It possesses both adenine and 2-OH-A DNA glycosylase activities.
Kim C.J., et.al., Oncogene 23:6820-6822(2004).Isidro G., et.al., Hum. Mutat. 24:353-354(2004).Sieber O.M., et.al., N. Engl. J. Med. 348:791-799(2003).
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