|Other Names||Histone H12, Histone H1c, Histone H1d, Histone H1s-1, HIST1H1C, H1F2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9164c was selected from the Center region of human HIST1H1C. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).|
|Cellular Location||Nucleus. Chromosome. Note=Mainly localizes in euchromatin. Distribution goes in parallel with DNA concentration|
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Provided below are standard protocols that you may find useful for product applications.
Histones H1 are necessary for the condensation of nucleosome chains into higher order structures.
Mayya V., et.al., Sci. Signal. 2:RA46-RA46(2009).
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