|Other Names||Lanosterol synthase, 3-epoxysqualene--lanosterol cyclase, Oxidosqualene--lanosterol cyclase, OSC, hOSC, LSS, OSC|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus.|
|Cellular Location||Endoplasmic reticulum membrane; Peripheral membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
LSS catalyzes the conversion of (S)-2,3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D.
Dang, H., et al. J. Biol. Chem. 284(10):6218-6226(2009)Lu, Y., et al. J. Lipid Res. 49(12):2582-2589(2008)Ma, J., et al. Atherosclerosis 191(1):63-72(2007)
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