|Other Names||Lanosterol synthase, 3-epoxysqualene--lanosterol cyclase, Oxidosqualene--lanosterol cyclase, OSC, hOSC, LSS, OSC|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9165b was selected from the C-term region of human LSS. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency.|
|Cellular Location||Endoplasmic reticulum membrane; Peripheral membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
The protein catalyzes the conversion of (S)-2,3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D.
Dang,H., et.al., J. Biol. Chem. 284 (10), 6218-6226 (2009)Lu,Y., et.al., J. Lipid Res. 49 (12), 2582-2589 (2008)
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