|Other Names||Potassium voltage-gated channel subfamily H member 7, Ether-a-go-go-related gene potassium channel 3, ERG-3, Eag-related protein 3, Ether-a-go-go-related protein 3, hERG-3, Voltage-gated potassium channel subunit Kv113, KCNH7, ERG3|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9169a was selected from the N-term region of human KCNH7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in prolactin-secreting adenomas.|
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Provided below are standard protocols that you may find useful for product applications.
KCNH7 represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This protein encodes a member of the potassium channel, voltage-gated, subfamily H.
Alkelai,A., et.al., Psychopharmacology (Berl.) 206 (3), 491-499 (2009)Couturier,N., et.al., Eur. J. Hum. Genet. 17 (6), 844-847 (2009)
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