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APOBEC3F Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q8IUX4
Clone Names 90819134
Peptide ID 90819134
Additional Information
Gene ID 200316
Other Names DNA dC->dU-editing enzyme APOBEC-3F, 354-, Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3F, A3F, APOBEC3F
Target/Specificity The synthetic peptide sequence used to generate the antibody AP9176a was selected from the N-term region of human APOBEC3F. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination- independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double- stranded RNA. Exhibits antiviral activity also against hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.
Cellular Location Cytoplasm. Cytoplasm, P-body.
Tissue Location Widely expressed. Highly expressed in ovary.
Research Areas
Citations (0)

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This protein is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control.


Khatua,A.K.,, Virology 400 (1), 68-75 (2010)Koning,F.A.,, J. Virol. 83 (18), 9474-9485 (2009)

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$ 80.00
Cat# BP9176a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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Ordering Information

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