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DCP2 Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q8IU60
Clone Names 90909169
Peptide ID 90909169
Additional Information
Gene ID 167227
Other Names m7GpppN-mRNA hydrolase, Nucleoside diphosphate-linked moiety X motif 20, Nudix motif 20, mRNA-decapping enzyme 2, hDpc, DCP2, NUDT20
Target/Specificity The synthetic peptide sequence used to generate the antibody AP9182c was selected from the Center region of human DCP2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DCP2
Synonyms NUDT20
Function Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety.
Cellular Location Cytoplasm, P-body. Nucleus. Note=Predominantly cytoplasmic, in processing bodies (PB). A minor amount is nuclear
Tissue Location Expressed in brain and testis. Not detected in heart (at protein level).
Research Areas
Citations (0)

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DCP2 is a key component of an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005).


Yamochi,T.,, Biochem. Biophys. Res. Commun. 370 (1), 195-199 (2008)Li,Y.,, Mol. Cell. Biol. 28 (3), 939-948 (2008)

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$ 80.00
Cat# BP9182c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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