|Other Names||Cytochrome c oxidase assembly protein COX15 homolog, COX15|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9183c was selected from the Center region of human COX15. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in the biosynthesis of heme A.|
|Cellular Location||Mitochondrion membrane; Multi-pass membrane protein|
|Tissue Location||Predominantly found in tissues characterized by high rates of oxidative phosphorylation (OxPhos), including muscle, heart, and brain.|
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Provided below are standard protocols that you may find useful for product applications.
COX15 is the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex.
Vitali,M., et.al., J Neural Transm 116 (12), 1635-1641 (2009)Dassa,E.P., et.al., EMBO Mol Med 1 (1), 30-36 (2009)
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