|Other Names||Elongator complex protein 4, hELP4, PAX6 neighbor gene protein, ELP4, C11orf19, PAXNEB|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9192b was selected from the C-term region of human ELP4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4.|
|Cellular Location||Cytoplasm. Nucleus.|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
ELP4 encodes a component of the six subunit elongator complex, a histone acetyltransferase complex that associates directly with RNA polymerase II during transcriptional elongation. The human protein can partially complement sensitivity phenotypes of yeast ELP4 deletion mutants.
Strug,L.J., et.al., Eur. J. Hum. Genet. 17 (9), 1171-1181 (2009)Miele,A., et.al, J. Cell. Biochem. 102 (1), 136-148 (2007)
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