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ELP4 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q96EB1
Clone Names 91009009
Additional Information
Gene ID 26610
Other Names Elongator complex protein 4, hELP4, PAX6 neighbor gene protein, ELP4, C11orf19, PAXNEB
Target/Specificity The synthetic peptide sequence used to generate the antibody AP9192b was selected from the C-term region of human ELP4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ELP4
Synonyms C11orf19, PAXNEB
Function Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29332244). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244).
Cellular Location Cytoplasm. Nucleus
Tissue Location Widely expressed..
Research Areas
Citations (0)
citation

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Background

ELP4 encodes a component of the six subunit elongator complex, a histone acetyltransferase complex that associates directly with RNA polymerase II during transcriptional elongation. The human protein can partially complement sensitivity phenotypes of yeast ELP4 deletion mutants.

References

Strug,L.J., et.al., Eur. J. Hum. Genet. 17 (9), 1171-1181 (2009)Miele,A., et.al, J. Cell. Biochem. 102 (1), 136-148 (2007)

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$ 277.78
Cat# BP9192b
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