|Other Names||L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase, 278-, 4'-phosphopantetheinyl transferase, Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase, AASD-PPT, LYS5 ortholog, AASDHPPT|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP9193c was selected from the Center region of human AASDHPPT. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'- phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN.|
|Tissue Location||Detected in heart, skeletal muscle, placenta, testis, brain, pancreas, liver and kidney|
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Provided below are standard protocols that you may find useful for product applications.
AASDHPPT is similar to Saccharomyces cerevisiae LYS5, which is required for the activation of the alpha-aminoadipate dehydrogenase in the biosynthetic pathway of lysine. Yeast alpha-aminoadipate dehydrogenase converts alpha-biosynthetic-aminoadipate semialdehyde to alpha-aminoadipate. It has been suggested that defects in the human gene result in pipecolic acidemia.
Strickland,K.C., et.al,. J. Biol. Chem. 285 (3), 1627-1633 (2010)Bunkoczi,G., et.al, Chem. Biol. 14 (11), 1243-1253 (2007)
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