AASDHPPT Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9NRN7 |
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Clone Names | 90819005 |
Gene ID | 60496 |
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Other Names | L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase, 278-, 4'-phosphopantetheinyl transferase, Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase, AASD-PPT, LYS5 ortholog, AASDHPPT |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP9193c was selected from the Center region of human AASDHPPT. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | AASDHPPT |
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Function | Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'-phosphopantetheine moiety from coenzyme A, regardless of whether the CoA is presented in the free thiol form or as an acetyl thioester, to a serine residue of a broad range of acceptors including the acyl carrier domain of FASN. |
Cellular Location | Cytoplasm, cytosol. |
Tissue Location | Detected in heart, skeletal muscle, placenta, testis, brain, pancreas, liver and kidney |
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Provided below are standard protocols that you may find useful for product applications.
Background
AASDHPPT is similar to Saccharomyces cerevisiae LYS5, which is required for the activation of the alpha-aminoadipate dehydrogenase in the biosynthetic pathway of lysine. Yeast alpha-aminoadipate dehydrogenase converts alpha-biosynthetic-aminoadipate semialdehyde to alpha-aminoadipate. It has been suggested that defects in the human gene result in pipecolic acidemia.
References
Strickland,K.C., et.al,. J. Biol. Chem. 285 (3), 1627-1633 (2010)Bunkoczi,G., et.al, Chem. Biol. 14 (11), 1243-1253 (2007)
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